Dr. Steinbach’s basic, translational, and clinical research are focused on the pathogenesis, diagnosis, and treatment of invasive fungal infections. His laboratory centers on the molecular pathogenesis of the fungus Aspergillus fumigatus, targeting cell signaling pathways such as calcineurin and Hsp90 and their control over fungal growth, disease establishment, and antifungal resistance. His calcineurin biology work has defined numerous clinically-relevant and fungal-specific control points over virulence. Translational efforts focus on antifungal drug development, encompassing protein structure and targeting, animal models of disease, and designing and leading phase I-IV clinical trials. He is the co-founder and co-chairman of the biennial Advances Against Aspergillosis meetings, now the leading international meeting dedicated to Aspergillus care and research. Clinical research centers on his founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multi-national consortium dedicated to investigating the epidemiology, diagnosis, and treatment of invasive fungal infections in children and currently overseeing two large clinical trials. He has co-edited 5 books, serving as the co-editor of Aspergillus fumigatus and Aspergillosis, co-editor of the seminal Feigin & Cherry’s Textbook of Pediatric Infectious Diseases two-volume textbook, and co-editor of the American Academy of Pediatrics Nelson’s Antimicrobial Therapy textbook for anti-infectives in children, and lead editor of Pediatric Transplant and Oncology Infectious Diseases.
William J. Steinbach, MD