The research goal of Dr. Trivedi’s laboratory is to identify causal mechanisms of congenital cardiac and vascular diseases affecting human patients. His laboratory has uncovered essential roles of chromatin-modifying enzymes and signaling pathways in the pathogenesis of human diseases such as Emberger syndrome (Lymphedema), Noonan syndrome (Chylothorax and Lymphangiectasia), Hepatic cavernous hemangiomas, Aortic stenosis, Epithelioid hemangioendothelioma, Holt-Oram syndrome, and Mitochondrial diseases. These discoveries have opened new areas of investigation, identified fundamental developmental processes, and contributed to a roadmap for novel therapies.