Dr. Lavine is the principle investigator of a basic and translation science laboratory that is focused on understanding the importance and therapeutic implications of immune cell diversity in cardiovascular diseases. His group has discovered that the mouse and human heart contain distinct macrophage populations with divergent origins, repopulation dynamics, and functions. The laboratory serves as an outstanding training environment for physician scientists across all levels of scientific development including predoctoral and graduate students, postdoctoral fellows, and junior faculty members. Trainees have received their own independent support from the NIH and American Heart Association. Current projects within the laboratory are focused on understanding cardiac myeloid cell diversity using single cell omics, identifying molecular determinants of cell fate, and deciphering mechanisms by which monocytes, macrophages, and dendritic cells are mobilized, activated and mediate their effector functions. His grouped as developed and translated an imaging reagent to visualize inflammatory monocyte-derived macrophages in patients with a variety of cardiovascular diseases including ischemic and nonischemic forms of heart failure. Finally, his group is using mouse and engineered heart tissue systems to delineate targetable mechanisms that underlie different forms of pediatric and adult cardiomyopathy and to generate precision therapeutics. Dr. Lavine is a practicing board certified cardiologist with expertise in advanced heart failure and cardiac transplantation.
Kory J. Lavine, MD, PhD