I am interested in the regulation of protein metabolism, especially in muscle. We have identified the mechanisms causing the loss of muscle protein that occurs in response to chronic kidney disease and other catabolic conditions. Recently, we have uncovered potential methods that could block the loss of muscle mass. These mechanisms were confirmed in cultured muscle cells and in mice that were genetically engineered to address specific questions. Our results have defined how CKD, inflammation and insulin/IGF-1 responses stimulate the ubiquitin-proteasome stystem to degrade muscle proteins. Our goal is to develop these findings to a stage that can be tested in clinically relevant conditions.
William E. Mitch, MD