Gregory J. Gores, M.D. is a quintessential, senior academician; a “quadruple threat” with contributions to research, clinical practice, education, and leadership. His research contributions include sustained federal funding (greater than 30 years), over 650 publications, an H-index of 128, and over 50,000 citations (Scopus data base). Based on these accomplishments, he was appointed as a Distinguished Mayo Investigator. His clinical focus on hepatobiliary neoplasia has led to novel protocols regarding liver transplantation for cholangiocarcinoma. Educational activities include mentoring over 80 fellows, and directing a liver transplant fellowship program. These activities have been recognized by receipt of an American Gastroenterological Association Mentorship Award. Extramural leadership positions include past presidency of the American Association for the Study of Liver Disease (AASLD) and the International Liver Cancer Association, and a past Councilor of the American Gastroenterological Association (AGA). Intramural positions include serving as past Chair of the Gastroenterology and Hepatology Division at Mayo Clinic Rochester, Medical Director of the Liver Transplant Program, and current Executive Dean for Research across the Mayo enterprise. His stature and accomplishments were recently recognized by prestigious awards from the Mayo Alumni Association, the AASLD, the German Society of Gastroenterology, and the Canadian Liver Foundation and Canadian Association for the Study of Liver.