Dr. Moe is the Director of the Division of Nephrology in the Department of Medicine at Indiana University School of Medicine. She is the Stuart A. Kleit Professor of Medicine, and a Distinguished Professor at Indiana University- the top academic honor of the institution. She also served as President of the American Society of Nephrology in 2014. Dr. Moe received her medical degree from the University of Illinois College of Medicine at Chicago. She completed her internship and residency in the Department of Internal Medicine at Loyola University Medical Center in Maywood, Illinois. Her research and clinical fellowships were completed in the Section of Nephrology of the Department of Medicine at the University of Chicago in Illinois. She has been a faculty member at Indiana University since 1992. Dr. Moe’s research interests are in disorders of bone and mineral metabolism in patients with chronic kidney disease, specifically renal osteodystrophy and vascular calcification and the relationship between the two diseases. She has examined the pathogenesis of vascular calcification in vivo and in vitro, determining that in dialysis patients vascular calcification is a cell mediated process, with de-differentiation of vascular smooth muscle cells to an osteoblast phenotype. This appears to be mediated by upregulation of the “osteoblast” transcription factor core binding factor alpha 1 (Cbfa1) as expression of Cbfa1 is upregulated by in situ hybridization in calcified arteries in dialysis patients, and in cultured vascular smooth muscle cells in response to pooled serum from dialysis patients. Studies in both patients with CKD and in an animal model of CKD she has examined the importance of diet in the regulation and treatment of CKD- Mineral Bone Disorder. Dr. Moe has been actively involved in new treatments for renal osteodystrophy in patients with chronic kidney disease including novel phosphate binders, different forms of vitamin D and calcimimetics.
Sharon Martin Moe, MD