Herbert Yih-Fuu Lin, MD, PhD
Dr. Lin's laboratory studies the role of the TGF-beta/BMP signaling pathways in health and disease. Dr. Lin's interest in the TGF-beta/BMP signaling system began when he participated in the cloning of the first signaling TGF-beta receptors, thus opening the field of TGF-beta signal transduction. More recently, Dr. Lin and his colleagues have identified a novel family of BMP co-receptors. How TGF-beta/BMP ligands interact with receptors, the role of TGF-beta/BMP signaling in the kidney, and the role of the RGM/Dragon/Hemojuvelin family of BMP co-receptors in the regulation of iron metabolism are areas of active research. Ultimately, by studying this complex but important signaling system, he and his colleagues hope to shed light on diseases such as chronic kidney disease, hemochromatosis and anemia of chronic disease.