Nikolaos G. Frangogiannis, MD
Dr Frangogiannis earned his medical degree from the University of Athens Medical School, then completed residency training in Internal Medicine (Clinical Investigator Pathway), and a fellowship in Cardiology, at Baylor College of Medicine. After completing his fellowship, he joined the faculty at Baylor. Dr Frangogiannis’ research explores the mechanisms of cardiac injury and repair. His laboratory has identified key molecular signals responsible for orchestrating the healing response in myocardial infarction. His research has focused on four main directions: a) The role of chemokine-mediated pathways in cardiac injury and repair. Current research studies the significance of specific chemokine/chemokine receptor interactions in recruitment of monocyte and lymphocyte subsets with anti-inflammatory properties. b) Signals involved in resolution of the inflammatory reaction and in containment of the fibrotic response following infarction. Dr Frangogiannis’ laboratory has identified endogenous molecular pathways preventing excessive inflammation and uncontrolled fibrosis following cardiac injury. c) The role of the dynamic alterations in the composition of the extracellular matrix network in modulating inflammatory pathways and cellular behavior in the injured and remodeling heart. d) The mechanisms involved in the pathogenesis of cardiac fibrosis in the cardiomyopathy associated with diabetes and obesity. The goal of the Frangogiannis laboratory is to identify therapeutic targets for attenuation of adverse remodeling following cardiac injury, thus preventing the development of heart failure.