Dr. Amy P. Abernethy, a palliative care physician and hematologist/oncologist, is Director of the Duke Center for Learning Health Care (CLHC) in the Duke Clinical Research Institute and Director of the Duke Cancer Care Research Program (DCCRP) in the Duke Cancer Institute. An internationally recognized expert in health services research, cancer informatics, and delivery in patient-centered cancer care, she directs a prolific research program (CLHC/DCCRP) that conducts patient-centered clinical trials, analyses, and policy studies; all CLHC/DCCRP studies make use of, and simultaneously contribute to the development of, an integrated data system that coordinates diverse datasets, leverages novel information technology for patient reporting of symptoms and other concerns, evaluates efficacy and/or effectiveness of a variety of therapeutic interventions, informs future studies, and facilitates clinical decision support, patient education, and patient-provider communication. Patient-reported information is central to this work. As a part of her focus on health policy, evidence synthesis, and comparative effectiveness research, Dr. Abernethy is Co-Chair of the NIH-funded Palliative Care Research Cooperative Group (PCRC), an appointee to the Institute of Medicine’s National Cancer Policy Forum, President of the American Academy of Hospice & Palliative Medicine, on the Board of Directors for the Personalized Medicine Coalition, on the Advisory Board for the Rapid Learning System for Cancer of the American Society of Clinical Oncology, and Co-Principal Investigator of an NIH-funded faculty development (K01) program in comparative effectiveness research at Duke. Dr. Abernethy participates integrally in current high-level national and international discussions about reforming the evidence development system, presenting a model for a rapid learning cancer clinic that coordinates clinical and research functions to better serve patients’ needs in an evidence-driven, cost-effective, and patient-centered manner.