Chronic liver disease is a common cause of death in the United States, and liver cancer incidence is growing faster than that of any other cancer. The Goessling laboratory seeks to understand the mechanisms that cause organ injury and the signals that regulate regenerative and malignant growth. Our specific interests are to define the similarities in important signaling pathways between development, regeneration and carcinogenesis of the liver, an important organ for the organism’s metabolism and protein synthesis with remarkable regenerative capacities. We investigate zebrafish as the primary model to discover novel regulatory pathways of liver development and evaluate their importance for recovery after toxic and physical injury, complemented by mouse models and organoids derived from human cell samples. Using chemical and genetic screens and targeted genetic modulation, we assess organ formation, repair and carcinogenesis by high-resolution in vivo imaging, single-cell and functional genomic methods, and other phenotype analyses to define the principal molecular and cellular mechanisms regulating organ growth. Our goal is to develop novel therapeutic approaches for patients with liver failure and cancer. 

I previously served as the chief of gastroenterology at the Massachusetts General Hospital and as the Director of the Harvard-MIT Division of Health Sciences and Technology (HST) and Advisory Dean of the Irving M. London Society at Harvard Medical School. I am currently the Chair of Internal Medicine at Yale School of Medicine and the Physician-in-Chief for Medicine for the Yale-New Haven Health System.