Our research group is interested in understanding hematopoiesis and innate immunity by deciphering the genetic etiology and pathophysiology of monogenic diseases. We have a particular interest in neutrophil granulocytes and have identified several human genetic defects associated with congenital neutropenia. Furthermore, we are interested in developing novel therapeutic strategies such as hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome and other primary immunodeficiency disorders. We have established the international Care-for-Rare Alliance for children with rare diseases.
Christoph Klein, MD, PhD