Dr. Rosano has made fundamental breakthroughs in our understanding of the brain’s potential to resist aging and disease. Dr. Rosano's research approach is unique in that it integrates methods from the fields of neuroimaging, geriatric medicine, epidemiology and neuroscience to implement novel strategies for improving brain health and function. Her work to date has characterized and contrasted “normal” brain aging in older adults and “accelerated” brain aging in adults exposed to chronic diseases, such as diabetes. Her work of ultra-structural neurovascular effects of physical activity interventions is on the cutting-edge and brings to light several promising targets to promote brain health.