Dr. Bisson's career goal is to use clinical research to improve the health of adults with Human Immunodeficiency Virus (HIV) and/or tuberculosis (TB). As an Associate Professor of Medicine and Epidemiology at the University of Pennsylvania, he has focused on relating how immune function relates to clinical outcomes in HIV/TB in order to identify new treatments and treatment strategies. Working extensively in sub-Saharan Africa, his work has elucidated how cellular immune function specific to mycobacteria relates to patient outcomes including pulmonary inflammation, lung function , immune reconstitution inflammatory syndrome, and survival. Ongoing studies are evaluating immune mediators of lung damage in HIV/TB, the role of inflammasomes in TB-associated inflammation, and imatinib besylate as a host-directed therapy for TB.
Gregory P. Bisson, MD, MSCE