While growing up in St. Louis, Missouri, Kevin spent summers working with recombinant erythropoietin in the laboratory of Greg Longmore at Washington University. He then studied English Literature at Harvard, and Medicine at Johns Hopkins. In Baltimore, Kevin became enamored with the prospect of using mouse genetic models of disease, observing Hal Dietz and his elegant models of Marfan syndrome. During residency in orthopaedic surgery at the University of Iowa, Kevin worked in the laboratory of Val Sheffield to develop the first mouse genetic model of multiple osteochondromas. Next, he pursued a surgical fellowship in musculoskeletal oncology at the University of Toronto, working at Mount Sinai and Princess Margaret Hospitals as well as the Hospital for Sick Children. His first faculty appointment in the Department of Orthopaedics at the University of Utah was accompanied by a mentored position in the laboratory of Mario Capecchi. Supported by a K08 award from the National Cancer Institute, as well as another career development award from the Damon Runyon Cancer Research Foundation, Kevin began developing mouse genetic models of osteosarcoma, peripheral chondrosarcoma, synovial sarcoma, and clear cell sarcoma with Mario. He then moved his independent laboratory program up to Huntsman Cancer Institute, where his clinical surgical practice was already established. There, with support from Alex’s Lemonade Stand Foundation, he developed the first mouse genetic model of alveolar soft part sarcoma. Through deep collaborations with Brad Cairns, a chromatin biochemist, Kevin currently pursues the mechanisms of aberrant SWI/SNF chromatin remodeling on synovial sarcomagenesis, as well as other mechanisms of epigenetic transcriptional regulation in translocation-associated sarcomas. He leads the Sarcoma Disease Center at Huntsman Cancer Institute and provides diagnostic and complex surgical management of the full range of musculoskeletal neoplastic diseases. He and his wife and their 4 teenagers enjoy the mountains that surround their home.
Kevin Bruce Jones, MD