Dr. Krzysztof Kiryluk, Associate Professor of Medicine, is a physician-scientist in the Division of Nephrology, Department of Medicine at Columbia University. He received his medical degree at the Columbia College of Physicians & Surgeons, completed his residency in Internal Medicine at the Massachusetts General Hospital, Nephrology fellowship at the NewYork-Presbyterian Hospital, Columbia University, and research training in biostatistics and statistical genetics at the Mailman School of Public Health.
Dr. Kiryluk's research aims to define genetic factors contributing to the risk of kidney disease and related traits in humans. He leads several large collaborative national and international genetic studies of glomerular disorders, including for IgA nephropathy and membranous nephropathy. He is investigating genetic regulators of IgA production and O-glycosylation, and their relationship to human disease. Dr. Kiryluk uses functional genomics and systems genetics approaches to elucidate molecular mechanisms underlying inherited kidney disorders. He is also developing novel approaches to identify genetic predictors of kidney allograft rejection using genome-wide donor-recipient compatibility studies.
Some of Dr. Kiryluk’s interests fall at the interface of research and clinical care. For example, he is interested in the development of new informatics methods to harness the power of “big data” (clinical and molecular) to enhance genetic discovery and improve clinical care of kidney patients. On this front, he is leading several local and national Precision Medicine efforts, including molecular studies of acute kidney injury within the NIDDK’s Kidney Precision Medicine Project (KPMP), or electronic kidney disease phenotyping efforts of the NHGRI’s Electronic Medical Records and Genomics (eMERGE) consortium.
Dr. Kiryluk is also actively involved in medical and research education. He directs the Renal Physiology & Pathophysiology Course for medical students at the Columbia College of Physicians & Surgeons, co-directs the Columbia Precision Medicine TL1 training program for pre- and post-doctoral students, and co-leads the Columbia CTSA Precision Medicine Resource.