Peter Hunt is a Professor of Medicine in the Division of Experimental Medicine at UCSF and Co-Director of the UCSF-Bay Area Center for AIDS Research for Basic and Translational Science. His primary research focus is on the inflammatory consequences of HIV infection. His translational research program seeks to understand both the causes and consequences of persistent immune activation in treated HIV infection, including its impact on age-related morbidity and mortality as well as HIV persistence. He also conducts pilot clinical trials of novel immune-based interventions designed to decrease immune activation and recently completed a term as Chair of the Inflammation Committee of the AIDS Clinical Trials Group (ACTG). His laboratory’s more recent work has focused on the impact of the inflammatory state on vaccine responsiveness and on the contribution of asymptomatic CMV infection to multiple inflammatory pathways in treated HIV infection. This latter work has led to a large clinical trial in the ACTG (A5383) and multiple linked NIH grants, which will assess whether treating asymptomatic CMV replication in treated HIV infection not only reduces systemic inflammation, but also reduces microbial translocation, arterial inflammation, central nervous system inflammation, neurocognitive dysfunction, and insulin resistance.
Peter William Hunt, MD