Dr. Pradeep Natarajan is the Director of Preventive Cardiology and the Paul and Phyllis Fireman Endowed Chair in Vascular Medicine at Massachusetts General Hospital, Associate Professor of Medicine at Harvard Medical School, Associate Member of the Broad Institute of Harvard and MIT. He received his BA in molecular biology with Honors and Phi Beta Kappa in 2004 from the University of California, Berkeley. He received his MD with Alpha Omega Alpha in 2008 from the University of California, San Francisco. He received his MMSc in biomedical informatics in 2015 from Harvard Medical School. Dr. Natarajan completed his internship and residency in internal medicine at the Brigham and Women’s Hospital in 2011. He completed his clinical and research fellowship in cardiovascular medicine at the Massachusetts General Hospital in 2015.
Dr. Natarajan leads an interdisciplinary research group using emerging methods in biomedical informatics and human investigation to leverage naturally occurring germline as well as acquired human genetic variation to advance the prevention of cardiovascular diseases, particularly atherosclerotic cardiovascular disease. He leads several consortia to use genetic epidemiology, large-scale sequencing studies, genotype-driven human investigation, and genetic testing implementation. Among his scientific contributions, he has pioneered ‘human knockout’ discovery and investigation to prioritize therapeutic targets, monogenic and polygenic characterization of heritable traits through whole genome sequencing, and the novel concept of somatic mutations contributing to cardiovascular disease.
In tandem his research efforts, Dr. Natarajan oversees clinical and training programs on the prevention and genetics of cardiometabolic diseases, leading the MGH Cardiovascular Disease Prevention Center. His clinical program represents a nexus of high-quality evidence-based clinical medicine bidirectionally informing his translational research efforts.