Dr. Sid Puram is the Lindburg Professor and Chair of the Department of Otolaryngology-Head and Neck Surgery at Washington University in St. Louis. He has also served as the Director of the Head and Neck Tumor Center at Siteman since 2023. Dr. Puram graduated from MIT, followed by an MD-PhD at Harvard Medical School. He went on to residency at Harvard/Massachusetts Eye and Ear with an in-folded postdoctoral fellowship with Drs. Bradley Bernstein and Aviv Regev at the MIT Broad Institute/Massachusetts General. Thereafter, he completed a surgical oncology/microvascular free flap fellowship at the James Cancer Center/Ohio State University. Currently, Dr. Puram maintains a clinical practice focused on head and neck oncologic surgery, including transoral robotic surgery, open skull base approaches, and microvascular reconstruction. His multiple R01-funded group has been a leader in genetic, transcriptional, and epigenetic heterogeneity in head and neck cancer and its relationship to cancer phenotypes including metastasis and treatment response, with pioneering work in single cell sequencing. He has published over 180 peer-reviewed articles, including studies in Nature, Cell, and Nature Genetics, and delivered over 50 invited national and international lectures. He is Co-Chair of the NCI Clinical Proteomic Tumor Analysis Consortium Thyroid Working Group, Co-Chair of the NRG Oncology Head and Neck Translational Committee, Past Chair of the Microvascular Committee for the American Academy of Otolaryngology-Head and Neck Surgery, and an active member of the NCI Recurrent/Metastatic Task Force and NRG Head and Neck Core Committee.