Dr. Gupta is an Associate Professor of Medicine at Harvard Medical School and cardiologist at Brigham and Women’s Hospital (BWH). He graduated from the University of Pennsylvania School of Medicine (2007), completed Internal Medicine residency at Massachusetts General Hospital (2010), Cardiovascular Medicine fellowship at BWH (2014), and a postdoctoral fellowship in Human Genetics at the Broad Institute where he contributed to genome-wide association studies for coronary artery disease and established new methods for studying the function of non-lipid genetic associations. Dr. Gupta established his laboratory in the Divisions of Genetics and Cardiovascular Medicine at BWH where he has made seminal discoveries in the genetic risk of vascular disease. He pioneered the use of single cell RNA-sequencing to characterize endothelial cell heterogeneity. With large scale CRISPR perturbation studies he identified the common pathways which link multiple coronary artery disease risk loci. This approach identified 41 risk variants linked to endothelial cell shear stress response and implicated genetic variants in genes previously associated with rare cerebrovascular disease. This finding that rare and common diseases share genetic risk pathways motivates Dr. Gupta’s clinical focus in the Cardiovascular Genetics Center. He directs the vascular disease genetics program and sees patients with rare vascular diseases such as Marfan Syndrome, genetic aortopathies, and other vascular malformations.

Dr. Gupta has received awards recognizing his research, teaching, and patient care. He received the Loscalzo Prize for Best Basic Science/Translational paper in the journal Circulation in 2020. He won the Paul Dudley White Award for top abstract at the American Heart Association Vascular Discovery meeting (2022), and the Eugene Braunwald Junior Faculty Scholar Award from BWH. His research has been funded by the NIH Director’s New Innovator Award (2019-2024), NHLBI R01 and U01 grants, and the Chan Zuckerberg Foundation.