My labs interest is to understand development and diseases of the urogenital and nervous systems.  One of our main objective is to define how the kidneys and the lower urinary tract are organized to conduct their normal functions and the changes that occur in acute and chronic diseases across life span. By building this foundational knowledge and then using it as a benchmark to identify cells and molecules that alter during ageing or in disease, we hope to glean insights into slowing disease progression and extending the life span of the organ and the patient. This knowledge will be key in establishing the blueprint for engineering these organs to supplement kidney function.  We heavily use single cell and spatially resolved 2D and 3D multiomics technologies at cellular scale using human tissue to achieve our goals. We also use genetic models to further understand mechanisms of kidney development, regeneration and repair and harmonize model system and human datasets.