Juan P. Brito, M.D., is a Professor of Medicine at Mayo Clinic and an internationally recognized physician-scientist whose work bridges endocrinology, health services research, and artificial intelligence. His research has reshaped care for thyroid disorders by advancing active surveillance strategies for small, low-risk thyroid cancers and uncovering the overuse of levothyroxine in cases of mild hypothyroidism. These contributions have changed clinical guidelines, influenced policy, and promoted more patient-centered, evidence-based care.

Dr. Brito leads a research program focused on developing AI-driven tools that transform how endocrine conditions are diagnosed and managed. His innovations include predictive models for levothyroxine appropriateness, automated classification of thyroid pathology reports, virtual thyroid cancer registries, and the use of AI to evaluate shared decision-making in clinical encounters. A consistent theme in his work is the use of technology to support—not replace—human connection in healthcare.

He has authored over 250 peer-reviewed publications, with an H-index of 56, and holds three R01-level NIH grants, including an R37 MERIT Award from the National Cancer Institute. He serves as lead methodologist for the Endocrine Society and is a guideline task force member for the American Thyroid Association Guideline for the management of hypothyroidism. His leadership roles at Mayo Clinic include Chair of Innovation and Quality in the Division of Endocrinology, Medical Director of the Shared Decision-Making National Resource Center, and former Director of Late-Stage Translational Research for the Center for Clinical and Translational Science.

Dr. Brito’s work has been recognized with the Van Meter Award (ATA), the Early Investigator Award (Endocrine Society), the Rising Star in Endocrinology Award (AACE), and the 2025 Mayo Clinic Alumni Early Career Award for Research. His career reflects a deep commitment to integrating scientific rigor, clinical relevance, and patient values in advancing care.