Neil Romberg, MD is a clinical and translational immunologist, the Jeffery Modell Endowed Chair of Pediatric Immunology Research and an Associate Professor at the Perelman School of Medicine at the University of Pennsylvania. He is a founding member of the Immune Dysregulation program at the Children’s Hospital of Philadelphia, a multidisciplinary subspecialty team tasked with assessing and treating the most critically inflamed pediatric patients. Dr. Romberg was clinically trained at New York University (Pediatrics) and Yale University (Allergy and Clinical Immunology). He completed post-doctoral fellowships while at Yale in Immunobiology and Genetics under the supervision of Eric Meffre, PhD and Richard Lifton, MD, PhD before transitioning to independence. Dr. Romberg’s NIH-funded translational research program is devoted to identifying novel inborn errors of immunity, determining their molecular mechanisms and developing personalized therapies to treat affected children. He has discovered the proteins/genes causing congenital immunodeficiency (PU.1), autoinflammatory (NLRC4), and polyautoimmunity disorders (CD40LG). Dr. Romberg has also used advanced epigenetic tools to identify the cell-type specific non-coding genomic regions contributing to complex diseases like lupus and COVID-19. His laboratory has further leveraged biospecimens from patients with rare and common diseases to illuminate the molecular basis of human early B-cell tolerance and organization of the germinal center regulatory regime. Through national and international collaborations, Dr. Romberg’s research group has been early adaptor of cutting-edge molecular technologies including next-generation sequencing, multi-omics, CRISPR screens, multiplexed tissue imaging, lymphoid organoids and in vitro models of hematopoiesis. He is actively engaged in mentoring aspiring translational researchers in graduate school, clinical training, and post-doctoral positions.