Dr. Paige Porrett grew up in rural Michigan and was the first in her family to attend college. She obtained a Bachelor of Arts in French from Northwestern University in Evanston, IL and subsequently matriculated to the Northwestern Feinberg School of Medicine in Chicago. Continuing training at the University of Pennsylvania, Dr. Porrett took a four-year hiatus from her general surgery residency after her third year to pursue a PhD in immunology at Penn under the mentorship of Dr. Laurence Turka. After completion of her general surgery residency, Dr. Porrett subsequently completed a transplant surgery fellowship and joined the Penn faculty, where she began her independent basic science laboratory studying pregnancy immunobiology and alloimmunization using transgenic mouse models. She synthesized her intellectual interests and clinical expertise when she started the third uterus transplant (UTx) program in the United States as the co-principal investigator of Penn’s UNTIL trial. She was recruited to the University of Alabama at Birmingham in 2020 where she was appointed the Director of Clinical & Translational Research and inaugural Director of VCA Transplantation for the UAB Comprehensive Transplant Institute. In this role, she built the fourth UTx program in the country. Dr. Porrett directs an NIH-funded laboratory studying immunobiology of pregnancy and has focused her studies on regional immunity of the human uterus. Her laboratory has recently discovered that molecular programs governing tissue residency in uterine NK cells – a population critical for normal placentation – are sensitive to calcineurin inhibitors and are reduced in the endometrium of UTx recipients. Dr. Porrett is a founding member and past-president of the US Uterus Transplant Consortium and founding member and current president-elect of the International Society of Uterus Transplantation.