Ed Stites, MD, PhD, is an Associate Professor in the Department of Laboratory Medicine at the Yale School of Medicine.  His experimental and computational research laboratory brings ideas from mathematics to the study of disease and its treatment, with an emphasis on cancer.  His research group has focused heavily upon the RAS oncogenes.  A mathematical model of the biochemical reactions that regulate RAS signals, and which Ed developed as a graduate student, continues to serve as a foundation for a wide variety of investigations into RAS biology and regarding the systems biology of disease.  This research program in the computational systems biology of oncogenes and proto-oncogenes has now been extended to RAF kinases, the EGFR receptor tyrosine kinase, and oncogenic G-protein coupled receptor signaling.  The lab has separately developed methods to statistically reduce biases that are present in cancer genomic data through the integration of cancer epidemiology with cancer genomics, along with the adaptation and incorporation of bias correction statistical methods.