Andrew P. Landstrom, MD, PhD, is a physician-scientist, Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania, and Director of Translational Research for the Children's Hospital of Philadelphia Cardiovascular Institute. His research focuses on defining the genetic and molecular mechanisms underlying heritable cardiovascular disease and translating these discoveries into predictive genomics, precision diagnostics, and precision therapeutics targeted to the molecular mechanisms of disease pathogenesis. His laboratory has identified fundamental mechanisms responsible for the development of inherited arrhythmias and cardiomyopathies.  This includes the discovery of TAX1BP3 as a cause of pediatric arrhythmogenic cardiomyopathy, ATP1A3 as a cause of short QT syndrome and sudden cardiac death, and the developmental role of PRDM16 in infant-onset left ventricular noncompaction cardiomyopathy. Building on these discoveries, his program integrates human genetics, stem cell biology, in vivo models, population genomics, and computational biology to identify new disease genes, define disease mechanisms, develop genomic prediction models that identify individuals at risk before disease manifests clinically, and develop mechanism-directed precision therapies.

Dr. Landstrom is a leader in cardiovascular genomics, pediatric inherited heart disease, and precision medicine. He leads national and international efforts to establish standards for cardiovascular genetic testing, interpretation of incidentally identified pathogenic variants, genomic medicine, precision therapeutics, and gene-based therapies through clinical practice guidelines, scientific policy statements, and international consensus documents. His work has helped shape the responsible integration of genomic medicine into pediatric cardiovascular care while advancing translational frameworks that accelerate the development and clinical implementation of emerging therapies for heritable cardiovascular disease.  Clinically, Dr. Landstrom specializes in the care of children and families with inherited arrhythmia syndromes, arrhythmic cardiomyopathies, and unexplained sudden cardiac arrest. As Director of Translational Research for the CHOP Cardiovascular Institute, he leads initiatives that integrate basic discovery, translational science, and clinical investigation to accelerate first-in-child therapeutic development and improve outcomes for children with inherited cardiovascular disease.